ABSTRACT
With the increasing number of patients waiting for liver transplantation worldwide, the development of living donor liver transplantation can not only alleviate the shortage of donor liver, but also expand the donor pool. Compared with classical liver transplantation, living donor liver transplantation is more complex and delicate in surgical operation, with many problems to be further discussed and solved. The authors retrospectively analyze relevant research results, combined with clinical practice, investigate the selection and evaluation of donor, selection of donor liver, surgical innovation and treatment of hepatocellular carcinoma in living donor liver transplan-tation, in order to provide helps for alleviating the shortage of donor liver and improving the prognosis of recipients.
ABSTRACT
Histone modification participates in the occurrence and development of the diseases though affecting gene transcrip-tion activity by acetylation,methylation,phosphorylation,and other forms.It is an important field in the study of epigenetics. Numerous studies have demonstrated that histone modification plays an important role in the occurrence and development of liv-er diseases.This paper reviews the recent progress in under-standing the role and mechanisms of histone modification in alco-holic liver disease,nonalcoholic fatty liver disease,viral hepati-tis,liver fibrosis and hepatocellular carcinoma,with an aim to provide a theoretical basis for the treatment of liver diseases and drug development.